Anders Ståhlberg

Principal investigator at University of Gothenburg / Sahlgrenska University Hospital

Anders Ståhlberg is working as principal investigator at the Sahlgrenska Cancer Center, University of Gothenburg and Sahlgrenska University Hospital in Sweden. He has a PhD in molecular biotechnology and has two post-doc periods working with human embryonic stem cells and tumor biology. Anders primary research interest is to understand molecular mechanisms in tumor initiation and tumor development, focusing on breast cancer and sarcomas.

He has a PhD in molecular biotechnology and has two post-doc periods working with human embryonic stem cells and tumor biology. Anders primary research interest is to understand molecular mechanisms in tumor initiation and tumor development, focusing on breast cancer and sarcomas.

He has developed several strategies for DNA and RNA, especially at the single-cell and single-molecule level. Anders is also leading a Translational Genomics Platform at Sahlgrenska University Hospital, Sweden, which is a research initiative with the attempt to bring liquid biopsy analysis into healthcare.

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Title: Technical and biological challenges when analyzing cell-free tumor DNA

  • Analysis of circulating cell-free tumor DNA (ctDNA) in liquid biopsies offers new means for early cancer diagnostics, real-time monitoring of treatment efficiency and detection of relapse. Despite its potential use ctDNA remains challenging to detect and to quantify as it represents only a small fraction of all cell-free DNA
  • We have developed SiMSen-Seq, that allows allele frequencies < 0.1% to be detected. SiMSen-Seq is simple to perform, flexible in multiplexing and requires minimal DNA input. Here, we will present recent updates
  • Here, we discuss important considerations for ctDNA analysis in plasma, including all experimental steps from sampling to data interpretation. Furthermore, the use of quality control assays enables the development of robust and standardized workflows that facilitate the implementation of ctDNA analysis into clinical routine
  • We will show data from various ongoing studies, related to both clinical and basic research questions

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